Core Tools |
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Denovo motif discovery of target regions using STREME |
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Denovo motif discovery of target regions using DREME |
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Identify motifs with MEME |
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Run TomTom on target motifs |
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Motif enrichment using AME |
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Find instances of motifs using FIMO |
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Utilities |
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Check user's MEME install |
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Returns logical vector indicating valid MEME-Suite install status |
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Get sequence from GRanges |
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Add nucleic acid sequence of regions to metadata column |
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Write fasta file from stringset |
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Data Visualization |
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Compare top tomtom hits to original motif |
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Visualize a heatmap of aligned sequences |
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Plot AME heatmap clustered by similarity in detected motifs |
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Compare AME heatmap methods |
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Motif Manipulation |
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Remove duplicated motif entries |
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Check for duplicated motif matrices |
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Data Helpers |
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Force best tomtom match by id |
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Update best match info by ranking of tomtom data |
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Drop best match columns from tomtom results |
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Nest TomTom results columns into a data.frame column named "tomtom" |
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Data Import |
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Import Streme output from previous run |
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Import Dreme output from previous run |
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Import tomtom data from previous run |
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Parse AME output |
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Import FIMO results |
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Import MEME results |
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Example Datasets |
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Example runAme() output |
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runAme() output for example_chip_summits split by binding description |
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Annotated Transcription Factor ChIP-seq summits |
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Example runDreme() output |
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runDreme() output for example_chip_summits split by binding description |
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Example runDreme() output after passing to runTomTom() |
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Example runFimo() output |
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Example ChIP-seq peaks |
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RNAseq data from Early and Late Drosophila wings |
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Example runTomTom() output |